{"id":252,"date":"2024-10-30T20:01:41","date_gmt":"2024-10-30T20:01:41","guid":{"rendered":"https:\/\/iims.uthscsa.edu\/isrn\/?page_id=252"},"modified":"2024-11-07T16:31:14","modified_gmt":"2024-11-07T16:31:14","slug":"evaluating-the-implementation-of-an-extended-infusion-piperacillin-tazabactam-dosing-strategy-at-a-large-quaternary-care-teaching-hospital-abstract","status":"publish","type":"page","link":"https:\/\/iims.uthscsa.edu\/isrn\/resources\/ereading-room\/abstracts\/evaluating-the-implementation-of-an-extended-infusion-piperacillin-tazabactam-dosing-strategy-at-a-large-quaternary-care-teaching-hospital-abstract\/","title":{"rendered":"Evaluating the Implementation of an Extended Infusion Piperacillin – Tazabactam Dosing Strategy at a Large Quaternary Care Teaching Hospital"},"content":{"rendered":"

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Primary Author:<\/td>\nRubiya Azmiree, PharmD, BCPS<\/td>\n<\/tr>\n
Co-Principal Investigators\/Collaborators:<\/td>\nRehana Jamali, PharmD, Leonard T. Langino, MS, RPh, Bruce Hirsch, MD<\/td>\n<\/tr>\n
Organization<\/td>\nNorth Shore University Hospital<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Abstract<\/h2>\n

Purpose<\/h3>\n

The objective of this study was to evaluate the implementation of an automatic interchange of piperacillin-tazobactam from a 30 minute-intermittent infusion to a 4 hour-extended infusion dosing strategy.<\/p>\n

Background<\/h3>\n

Piperacillin-tazobactam is a broad spectrum \u03b2-lactam-\u03b2-lactamase inhibitor commonly used at our institution. Piperacillin-tazobactam is traditionally dosed intermittently every 6 hours and infused over 30 minutes1. Pharmacokinetic-pharmacodynamic characteristics of \u03b2-lactams display time dependent bactericidal effects. This implies that the important relationship for these antibiotics is the duration that drug concentrations exceed the mean inhibitory concentration (MIC)2 . Furthermore, Monte Carlo simulation has shown that a 4 hour extended infusion dosing regimen has the highest probability of achieving the drug exposure target associated with maximal microbiological effect across a range of MICs3.<\/p>\n

Thus, the decision to adapt an extended infusion piperacillin-tazobactam dosing strategy was made. We implemented an automatic interchange strategy to convert patients receiving traditional intermittent infusion to extended infusion piperacillin-tazobactam. Optimizing the pharmacokinetic-pharmacodynamic profile of the drug and reducing the patient\u2019s total drug exposure are both important quality assurance issues and would increase probability of attaining a good clinical outcome.<\/p>\n

Materials & Methods<\/h3>\n